HIV may kill majority of cells by a method overlooked for years

时间:2019-03-02 04:01:01166网络整理admin

AFTER all these years, HIV can still take us by surprise. Until recently, we thought HIV largely spread through the body as free-floating particles. Now we know that the virus can infect immune cells by being pumped directly from one cell into another, during brief connections between the two. Research using newer tissue culture methods suggest that crucial white cells called CD4 T-cells are killed by this cell-to-cell transmission up to 95 per cent of the time (Cell Reports, This mode of infection could be thousands of times more efficient than single viruses infecting cells from the blood. This may help explain why efforts to develop HIV vaccines have so far proved fruitless. When viruses are inside cells, they may be more likely to escape destruction by antibodies,